Antibacterial activity and molecular docking studies of series hydroxyxanthone

Abstract

Antibacterial assay of series hydroxyxanthone that was a synthesis via cyclization of phenol derivatives and acid derivatives with Eaton Reagent has been investigated through Escherichia coli, Bacillus cereus, Staphylococcus aureus and Salmonella typhimurium by diffusion well method. The possess antibacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA) has been reported by molecular docking. The result reveals that the 1,3,6-tryhydroxyxanthone were effective in inhibiting the growth of Escherichia coli, Bacillus cereus, Staphylococcus aureus and Salmonella typhimurium in the inhibition zone of 30, 30, 35, than 34 mm respectively with MIC at 10%. There was a binding interaction between 1,3,6-tryhydroxyxanthone and the amino acid residues such as His38, His35, Val177, Lys150 and Met41 into methicillin-resistant Staphylococcus aureus (MRSA) (2x3f.pdb).