Synthesis, acaricidal activities and docking study of novel acrylonitrile derivatives

Abstract

A series of novel acrylonitrile derivatives containing a flexible chain were designed using cyflumetofen as lead compound. They were synthesized via two steps. The structures were confirmed by 1H NMR13C NMR and HRMS. The title acrylonitrile derivatives exhibited good acaricidal activity against Tetranchus urticae. In particular, 3j possessed excellent activity in the green house, at the same level as the control Cyflumetofen at 4 days or 7 days.