Solid Phase Synthesis of Biologically active Benzimidazole Derivatives Catalysed by CH3 SO3 H-SiO2 Under Solvent free Condition

Abstract

A simple an expeditious method was established for the synthesis of 2-Substituted-1H- Benzimidazole derivatives at 90oC using o-phenylenediamine and different aldehydes. It has been found that a mixture of Methanesulphonic acid-SiO2 to be an effective catalyst to generate moderate to high yield of a wide variety of 2-substituted benzimidazole derivatives through a simple workup process. Solid phase, rapid reaction, solvent free technique and simplicity of the reaction procedure are the advantages of this protocol. R2