The role of the hippocampus in avoidance learning and anxiety vulnerability

Citations of this article
Mendeley users who have this article in their library.


The hippocampus has been implicated in anxiety disorders and post-traumatic stress disorder (PTSD); human studies suggest that a dysfunctional hippocampusmay be a vulnerability factor for the development of PTSD. In the current study, we examined the effect of hippocampal damage in avoidance learning, as avoidance is a core symptom of all anxiety disorders. First, the effect of hippocampal damage on avoidance learning was investigated in outbred Sprague Dawley (SD) rats. Second, the function of the hippocampus inWistar- Kyoto (WKY) rats was compared to SD rats. The WKY rat is an animal model of behavioral inhibition, a risk factor for anxiety, and demonstrates abnormal avoidance learning, marked by facilitated avoidance acquisition and resistance to extinction. The results of the current study indicate that hippocampal damage in SD rats leads to impaired extinction of avoidance learning similar toWKY rats. Furthermore,WKY rats have reduced hippocampal volume and impaired hippocampal synaptic plasticity as compared to SD rats.These results suggest that hippocampal dysfunction enhances the development of persistent avoidance responding and, thus, may confer vulnerability to the development of anxiety disorders and PTSD. © 2014 Cominski, Jiao, Catuzzi, Stewartand Pang.




Cominski, T. P., Jiao, X., Catuzzi, J. E., Stewart, A. L., & Pang, K. C. H. (2014). The role of the hippocampus in avoidance learning and anxiety vulnerability. Frontiers in Behavioral Neuroscience, 8(AUG).

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free