The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine

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Abstract

The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.

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Garavito, G., Bertani, S., Quiliano, M., Valentin, A., Aldana, I., & Deharo, E. (2012). The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine. Memorias Do Instituto Oswaldo Cruz, 107(6), 820–823. https://doi.org/10.1590/S0074-02762012000600019

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