Systolic aortic pressure-time area is a useful index describing arterial wave properties in rats with diabetes

Abstract

The accurate measurement of arterial wave properties in terms of arterial wave transit time (τw) and wave reflection factor (R f) requires simultaneous records of aortic pressure and flow signals. However, in clinical practice, it will be helpful to describe the pulsatile ventricular afterload using less-invasive parameters if possible. We investigated the possibility of systolic aortic pressure-time area (PTAs), calculated from the measured aortic pressure alone, acting as systolic workload imposed on the rat diabetic heart. Arterial wave reflections were derived using the impulse response function of the filtered aortic input impedance spectra. The cardiovascular condition in the rats with either type 1 or type 2 diabetes was characterized by (1) an elevation in PTAs; and (2) an increase in R f and decrease in τw. We found that an inverse linear correlation between PTAs and arterial τw reached significance (τw = 38.5462-0.0022 × PTAs; r = 0.7708, P < 0.0001). By contrast, as the PTAs increased, the reflection intensity increased: R f =-0.5439 + 0.0002 × PTAs; r = 0.8701; P <0.0001. All these findings suggested that as diabetes stiffened aortas, the augmented aortic PTAs might act as a useful index describing the diabetes-related deterioration in systolic ventricular workload.