Two-way traffic on the bridge from innate to adaptive immunity

Abstract

Conventional wisdom suggests that information is usually transmitted from the dendritic cell (DC) to the T cell. In this issue, Schwarz and Schwarz demonstrate that UV-induced T regulatory cells (Tregs) can influence the biology of nave DC. They report that IL-10-secreting Tregs prime DC to activate additional Tregs when injected into nave mice. It may be possible to use DCs that have been educated by Tregs to induce immune tolerance in vivo. © 2010 The Society for Investigative Dermatology.