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C5-Amino acid functionalized LNA: Positively poised for antisense applications

Chemical Communications (2014) 50(64) 9007-9009
DOI: 10.1039/c4cc03623a
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Abstract

Incorporation of positively charged C5-amino acid functionalized LNA uridines into oligodeoxyribonucleotides (ONs) results in extraordinary RNA affinity, binding specificity and stability towards 3′-exonucleases. © The Partner Organisations 2014.

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Guenther, D. C., Kumar, P., Anderson, B. A., & Hrdlicka, P. J. (2014). C5-Amino acid functionalized LNA: Positively poised for antisense applications. Chemical Communications, 50(64), 9007–9009. https://doi.org/10.1039/c4cc03623a

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