Structure of gefitinib

Abstract

The crystal of the title compound, C22H24ClFN4O3, belongs to space group P1 with cell dimensions of a = 8.928(1), b = 9.717(2), c =12.604(2) Å, α = 93.31(1), and β = 97.12(1), and γ = 101.47(1)°. The final R value is 0.053. The quinazoline and benzene rings are nearly coplanar. The conformation is maintained by an intramolecular C-H·N hydrogen bond. The morpholine ring is almost perpendicular to the quinazoline ring. 2004 © The Japan Society for Analytical Chemistry.