PHARMACEUTICAL STANDARDIZATION OF BAKUCHI VATI: A MODIFIED DOSAGE FORM OF DHATRYADI YOGA

Abstract

Lots of medicinal formulations have been mentioned in Ayurvedic compendia to compete with need of all time availability, easy dispensing, palatability and efficacy. There are some demerits of these formulations such as large amount of dose, unpleasant palatability, less shelf life and difficulty in portability. Modification in the formulations without changing its efficacy is need of hour in today's era for the feasibility, palatability, minimum dose, easy administration, increased bioavailability and better shelf life. Present study was planned to Pharmaceutical standardization of Dhatryadi Yoga (a formulation of Emblica officinalis (Gaertn) mentioned in Gadanigraha and indicated in Shvitra (Leucoderma). This formulation is advised in powder form but it becomes inconvenient in terms of shelf life, palatability and fixed dose administration, hence it is converted into tablet form as Dhatri-Khadira Bhavit Bakuchi vati. Pharmaceutical preparation and analytical study of Dhatri-Khadira Bhavit Bakuchi vati was carried out at Dattatraya Ayurved Rasashala, Mahatma Gandhi Ayurveda Collage Hospital and Research center, Salod (H) Wardha, Maharashtra. The formulation was first tasted for organoleptic parameters such as odour and colour, physico-chemical analysis and microbial specifications testings were performed. Modified Bakuchi vati had brown color with no specific smell, average weight gain 8.53%. Analytical standards for Bakuchi vati such as loss on drying at 105oC, total ash, acid insoluble ash, alcohol soluble extractives, water soluble extractive, pH, hardness and tablet disintegration time were 7.5%, 7.8%, 2%, 17.6%, 15 %, 5.05 (10% aqueous solution), 4 kg and 15 minutes respectively.