Multi-modal evolutionary deep learning model for ovarian cancer diagnosis

Abstract

Ovarian cancer (OC) is a common reason for mortality among women. Deep learning has recently proven better performance in predicting OC stages and subtypes. However, most of the state-of-the-art deep learning models employ single modality data, which may afford low-level performance due to insufficient representation of important OC characteristics. Furthermore, these deep learning models still lack to the optimization of the model construction, which requires high computational cost to train and deploy them. In this work, a hybrid evolutionary deep learning model, using multi-modal data, is proposed. The established multi-modal fusion framework amalgamates gene modality alongside with histopathological image modality. Based on the different states and forms of each modality, we set up deep feature extraction network, respectively. This includes a predictive antlion-optimized long-short-term-memory model to process gene longitudinal data. Another predictive antlion-optimized convolutional neural network model is included to process histopathology images. The topology of each customized feature network is automatically set by the antlion optimization algorithm to make it realize better performance. After that the output from the two improved networks is fused based upon weighted linear aggregation. The deep fused features are finally used to predict OC stage. A number of assessment indicators was used to compare the proposed model to other nine multi-modal fusion models constructed using distinct evolutionary algorithms. This was conducted using a benchmark for OC and two benchmarks for breast and lung cancers. The results reveal that the proposed model is more precise and accurate in diagnosing OC and the other cancers.