Abstract
An atom-economical and practical synthesis of cis-N-benzenesulfonamide acylaziridines through the Baldwin rearrangement of various N-benzenesulfonamide isoxazolines has been reported. A detailed experimental study revealed the beneficial effect of microwaves and pointed out the crucial role of the temperature in the reaction course. Moderate to good yields and excellent cis stereoselectivities were achieved for 13 examples. © 2010 American Chemical Society.
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CITATION STYLE
Gayon, E., Debleds, O., Nicouleau, M., Lamaty, F., Van Der Lee, A., Vrancken, E., & Campagne, J. M. (2010). Highly diastereoselective baldwin rearrangement of isoxazolines into cis -acylaziridines. Journal of Organic Chemistry, 75(17), 6050–6053. https://doi.org/10.1021/jo101273d
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