Angioinvasive mucormycosis and paradoxical stroke: a case report

Abstract

See, stats, and : https : / / www . researchgate . net / publication / 303710187 Angioinvasive stroke : a Article DOI : 10 . 1099 / jmmcr . 0 . 005048 CITATIONS 0 READS 10 4 , including : Some : Hypotension Case Samuel - Blanchette The 6 SEE All - Blanchette . The . Introduction :Rhizopustypicallyresultsinacute,aggressiveandangioinvasiveinfection,particularlyinimmunosuppressedindividuals.Riskfactorsincludeimmunosuppressioninhaematologicmalignancy,uncontrolledhyperglycemia,ironoverloadstates,andolderchelatoragentssuchasdeferoxamine.CasePresentation:Wedescribeacaseofa33-year-oldfemalewithtransfusion-dependentbetathalassemiawhowasstartedonintravenousdeferipronetherapyandsubsequentlypresentedwitharetropharyngealabscess.Despiteintravenousbroadspectrumantibiotics,shecontinuedtodeteriorateanddevelopedaphasia.ACTscanofherheadshowedmultiplehypodensities.BloodculturesgrewRhizopusspeciesandasubsequenttransesophagealechocardiogramshowedamassintherightatriumwithapatentforamenovale.Conclusion:Althoughdeferiprone,anewerironchelatoragent,hasantifungalpropertiesinvivo,thiscaseillustratesthatangioinvasiveRhizopusinfectionscanoccurinpatientstreatedwithdeferiprone.