Hyperthermia Effect of Nanoclusters Governed by Interparticle Crystalline Structures

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Abstract

Magnetic nanoparticles have an important role as heat generators in magnetic fluid hyperthermia, a type of next-generation cancer treatment. Despite various trials to improve the heat generation capability of magnetic nanoparticles, iron oxide nanoparticles are the only approved heat generators for clinical applications, which require a large injection dose due to their low hyperthermia efficiency. In this study, iron oxide nanoclusters (NCs) with a highly enhanced hyperthermia effect and adjustable size were synthesized through a facile and simple solvothermal method. Among the samples, the NCs with a size of 25 nm showed the highest hyperthermia efficiency. Differently sized NCs exhibit inconsistent interparticle crystalline alignments, which affect their magnetic properties (e.g., coercivity and saturation magnetization). As a result, the optimal NCs exhibited a significantly enhanced heat generation efficiency compared with that of isolated iron oxide nanoparticles (ca. 7 nm), and their hyperthermia effect on skin cancer cells was confirmed.

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APA

Jeong, M., Lee, S., Song, D. Y., Kang, S., Shin, T. H., & Choi, J. S. (2021). Hyperthermia Effect of Nanoclusters Governed by Interparticle Crystalline Structures. ACS Omega, 6(46), 31161–31167. https://doi.org/10.1021/acsomega.1c04632

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