A facile synthesis of N-Fmoc protected amino/peptidyl Weinreb amides employing acid chlorides as key intermediates

Abstract

An efficient, cost effective method for the preparation of N-Fmoc á-amino/ peptidyl Weinreb amides from the corresponding acid chlorides has been described. The synthesis of acid chlorides was accelerated by ultrasonication and were coupled with N,O-dimethylhydroxylamine hydrochloride to obtain the title compounds. All the prepated compound were isolated as stable solids after workup and have been fully characterized by IR, 1H NMR, 13C NMR and mass spectroscopy. ©ARKAT USA, Inc.