Translational regulation of yersinia enterocolitica mRNA encoding a type III secretion substrate

Abstract

Background: Yersinia enterocolitica yopD, lcrH, and yscM1 control the expression of yopQ encoding a secretion substrate. Results: YopD associates with 30 S ribosomal particles, and YopD, LcrH, and YscM1 block yopQ mRNA translation. Conclusion: In response to environmental signals, Yersinia prevent yopQ expression by blocking the translation of its transcripts. Significance: These results demonstrate translational regulation for the Yersinia type III secretion pathway. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.