Principle: A tool for associating genes with diseases via network propagation

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Abstract

PRINCIPLE is a Java application implemented as a Cytoscape plug-in, based on a previously published algorithm, PRINCE. Given a query disease, it prioritizes disease-related genes based on their closeness in a protein-protein interaction network to genes causing phenotypically similar disorders to the query disease. © The Author 2011. Published by Oxford University Press. All rights reserved.

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Gottlieb, A., Magger, O., Berman, I., Ruppin, E., & Sharan, R. (2011). Principle: A tool for associating genes with diseases via network propagation. Bioinformatics, 27(23), 3325–3326. https://doi.org/10.1093/bioinformatics/btr584

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