Comparative evaluation of the inhibitory activities of the novel penicillanic acid sulfone Ro 48-1220 against β-lactamases that belong to groups 1, 2b, and 2be

Abstract

The inhibitory activity of the penicillanic acid sulfone Ro 48-1220 against group 1, 2b, and 2be β-lactamases was evaluated. Ro 48-1220 inhibited TEM and SHV enzymes as effectively as clavulanate and tazobactam. It also inhibited group 1 β-lactamases at lower concentrations than tazobactam. Ro 48-1220, at a concentration of 4 μg/ml, protected ceftriaxone and ceftazidime against strains producing group 1 and 2be β-lactamases.