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CRISPR/Cas9 offers a new tool for studying the role of chromatin architecture in disease pathogenesis Jin-Soo Kim

Genome Biology (2018) 19(1)
DOI: 10.1186/s13059-018-1569-z
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Abstract

A recent study used CRISPR/Cas9 to reveal long-range looping between disease-related genes and their regulatory elements that is mediated by the CCCTC-binding factor (CTCF) in prostate cancer.

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Guo, X., & Dean, A. (2018). CRISPR/Cas9 offers a new tool for studying the role of chromatin architecture in disease pathogenesis Jin-Soo Kim. Genome Biology, 19(1). https://doi.org/10.1186/s13059-018-1569-z

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