Hydroxyapatite/calcium alginate composite particles for hemostasis and alveolar bone regeneration in tooth extraction wounds

Abstract

Tooth extractions can lead to complications such as post-extraction bleeding and bone resorption, which may result in unfavorable outcomes for implant restoration afterwards. To strive for an optimal condition for further restoration procedures, appropriate strategies, such as hemostasis or bone regeneration, are encouraged to be employed. However, the existing products are failed to meet both needs. As a widely employed tissue engineering materials, hydroxyapatite and calcium alginate both have demonstrated excellent performance in osteogenesis. However, their inferior mechanical strength poses a major limitation to their use in supporting the contracted extraction socket, which can easily lead to alveolar crest atrophy and barely achieve satisfying results. Calcium alginate improves the mechanical strength of hydroxyapatite, enabling the formation of new bone tissue and degradable in vivo. In this study, we demonstrated the biocompatibility and haemostatic ability of nCA particles on a rat tooth extraction model. In addition, long-term observation has revealed minimal inflammation and bone tissue regeneration. Our findings suggest a promising insight for clinical applications in hemostasis and bone regeneration after tooth extraction.