Abstract
The Fe3O4 nanoparticles, tailored with maleimidyl 3-succinimidopropionate ligands, were conjugated with paclitaxel molecules that were attached with a poly(ethylene glycol) (PEG) spacer through a phosphodiester moiety at the (C-2')-OH position. The average number of paclitaxel molecules/nanoparticles was determined as 83. These nanoparticles liberated paclitaxel molecules upon exposure to phosphodiesterase. Copyright © 2008 American Chemical Society.
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CITATION STYLE
Hwu, J. R., Lin, Y. S., Josephrajan, T., Hsu, M. H., Cheng, F. Y., Yeh, C. S., … Shieh, D. B. (2009). Targeted paclitaxel by conjugation to iron oxide and gold nanoparticles. Journal of the American Chemical Society, 131(1), 66–68. https://doi.org/10.1021/ja804947u
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