Human mature neutrophils as atypical APC

Abstract

In this issue of Blood, Vono et al provide solid data demonstrating that human mature neutrophils can function as antigen-presenting cells (APCs) for memory T cells in vitro.1 Using a rhesus macaque model of vaccination, the authors further demonstrate that antigen-positive neutrophils are abundantly present in draining lymph nodes (dLNs) and spleen, and are fully competent in stimulating the proliferation of autologous antigen-specific memory T cells ex vivo.