Comprehensive assessment of the association between estrogen receptor of alpha polymorphisms and the risk of prostate cancer: Evidence from a meta-analysis

Abstract

We performed a meta analysis to access the relationship of estrogen receptor of alpha (ESRa) polymorphisms with the risk of prostate cancer (PC). Twenty-four casecontrol studies (including 5477 cases and 10708 controls) were recruited for metaanalysis. The strongest association with the risk of PC was observed between ESRa rs9340799 and rs2234693 under the two genotypic models of allele and codominance in the overall population (p < 0.05). Under the subgroup analysis of ethnicity, we observed that ESRa rs9340799 was significantly associated with the susceptibility to PC in European population (AvsG, p = 0.000; AAvsGG, p = 0.002), while there was no difference in Asian (AvsG, p = 0.493; AAvsGG, p = 0.736) or African population (AvsG, p = 0.800; AAvsGG, p = 0.788). The results also showed that significant association between rs2234693 and the susceptibility to PC in European (CvsT, p = 0.004; CCvsTT, p = 0.001) and Asian population (CvsT, p = 0.004; CCvsTT, p = 0.003), but not in African population (CvsT, p = 0.636; CCvsTT, p = 0.669). The meta-analysis indicated that ESRa rs9340799 and rs2234693 might contribute to susceptibility and development of PC in European population.