l-β-(5-Hydroxy-2-pyridyl)-alamne and L-β-(3-Hydroxyureido)-alanine from Streptomyces

Abstract

In the course of the chemical screening study on the metabolites from actinomycetes, two unusual amino acids were isolated: l-β-(5-Hydroxy-2-pyridyl)-alanine (1) and l-β-(3-hydroxyureido)-alanine (9). The structures of 1 and 9 were elucidated from the physico-chemical properties of these amino acids and derivatives, and supported by synthesis. Antibacterial activities of 1 and its methylester (2) were antagonized by L-tyrosine, and those of 9 and its derivative (17) by l-glutamine. © 1975, The Pharmaceutical Society of Japan. All rights reserved.