Erythropoietin and renal function in sickle-cell disease

Abstract

The relations between haemoglobin concentration, creatinine clearance, and the serum concentration of erythropoiesis-stimulating factor were assessed in 31 patients with homozygous sickle-cell disease. Haemoglobin concentrations fell significantly with decreasing creatinine clearance (r=0.58, p<0.001) and were positively correlated with the concentration of erythropoiesis-stimulating factor (r=0.65; p<0.001). These observations suggest that erythropoietin concentration is the factor limiting production of red cells in sickle-cell disease with renal insufficiency and have implications for treatment.