Synthesis and metal-complexation properties of a new hydroxypyrimidinone- functionalized sepharose

Abstract

The 1-hydroxy-2-(1H)-pyrimidinone derivative 4-(3-amino-propylamino)-1- hydroxy-2-(1H)-pyrimidinone (HOPY-PrN) was synthesized and its acid-base and complexation properties towards a set of metal ions (FeIII, Al III, and ThIV) were studied by potentiometry and spectrophotometry. The ligand was further immobilized in an epoxy-activated sepharose by chemical coupling through the aminoalkyl pendent group with the aim of improving its sequestering capacity for residual amounts of metals. The new hydroxypyrimidinone-functionalized sepharose shows a high chelating capacity for metal ions in the pH range 3-8, thus suggesting good perspectives for potential environmental applications. © Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.