Colorectal cancer

Abstract

Epidemiology Colorectal cancer (CRC) is a common disease associated with considerable morbidity and mortality, with more than 1 000 000 new patients and 500 000 deaths annually. CRC has a natural history of transition from precursor to malignant lesion that spans, on average, 10-15 years, providing a window of opportunity for effective interventions and prevention. CRC might be preventable in up to 90% of patients with: ▪ Lifestyle modifications (balanced diet; avoidance of smoking and alcohol; and moderate physical activity). These can prevent up to 50% of the CRC cases.