Toxicological aspects of the bioactive versatile sulphonamide-imine complexes of organosilicon (IV)

Abstract

Organosilicon(IV) derivatives of the types R2SiCl(L), R 2Si(L)2 and R3Si(L) (where, R=phenyl or methyl, L=sulphonamide-imine ligand) have been synthesized and characterized by elemental analyses, IR, 1H, and 29Si NMR spectroscopy. These data support the binding of nitrogen to silicon(IV) in R 2SiCl(L) and R3Si(L) complexes with a trigonal bipyramidal geometry. However, R2Si(L)2 type of complexes possess an octahedral geometry. The results of antimicrobial effects of some representative complexes on different species of pathogenic fungi and bacteria have also been recorded and discussed. All the complexes are monomeric in nature as indicated by their molecular weight deterrninations and conductivity measurements in dry DMF show them to be non-electrolytes. The ligand and its corresponding complexes have also been tested for their nematicidal activity and the findings have been discussed in the present paper.