A novel P450-based biocatalyst for the selective production of chiral 2-alkanols

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Abstract

A P450 monooxygenase from Nocardia farcinica (CYP154A8) catalyses the stereo- and regioselective hydroxylation of n-alkanes, still a challenging task in chemical catalysis. In a biphasic reaction system, the regioselectivity for the C2-position of C7-C9 alkanes was over 90%. The enzyme showed strict S-selectivity for all tested substrates, with enantiomeric excess (ee) of up to 91%. © Partner Organisations 2014.

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von Bühler, C. J., & Urlacher, V. B. (2014). A novel P450-based biocatalyst for the selective production of chiral 2-alkanols. Chemical Communications, 50(31), 4089–4091. https://doi.org/10.1039/c4cc00647j

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