Comparative genomic analysis reveals a possible novel Non-Tuberculous Mycobacterium species with high pathogenic potential

3Citations
Citations of this article
29Readers
Mendeley users who have this article in their library.

Abstract

Mycobacteria have been reported to cause a wide range of human diseases. We present the first whole-genome study of a Non-Tuberculous Mycobacterium, Mycobacterium sp. UM-CSW (referred to hereafter as UM-CSW), isolated from a patient diagnosed with bronchiectasis. Our data suggest that this clinical isolate is likely a novel mycobacterial species, supported by clear evidence from molecular phylogenetic, comparative genomic, ANI and AAI analyses. UM-CSW is closely related to the Mycobacterium avium complex. While it has characteristic features of an environmental bacterium, it also shows a high pathogenic potential with the presence of a wide variety of putative genes related to bacterial virulence and shares very similar pathogenomic profiles with the known pathogenic mycobacterial species. Thus, we conclude that this possible novel Mycobacterium species should be tightly monitored for its possible causative role in human infections.

Cite

CITATION STYLE

APA

Choo, S. W., Dutta, A., Wong, G. J., Wee, W. Y., Ang, M. Y., & Siow, C. C. (2016). Comparative genomic analysis reveals a possible novel Non-Tuberculous Mycobacterium species with high pathogenic potential. PLoS ONE, 11(4). https://doi.org/10.1371/journal.pone.0150413

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free