Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator

  • Kato N
  • Lan K
  • Ono-Nita S
  • et al.
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Abstract

The hepatitis C virus (HCV) nonstructural region 5A (NS5A) protein, without its 146 amino-terminal amino acids and fused to the DNA-binding domain of GAL4, strongly activates transcription in yeast and human hepatoma cells. Transcriptional activation by the HCV NS5A protein may play a role in viral replication and hepatocarcinogenesis.

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Kato, N., Lan, K. H., Ono-Nita, S. K., Shiratori, Y., & Omata, M. (1997). Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator. Journal of Virology, 71(11), 8856–8859. https://doi.org/10.1128/jvi.71.11.8856-8859.1997

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