Stability of CHIKV infection models with CHIKV-monocyte and infected-monocyte saturated incidences

Abstract

We study the global stability of within-host Chikungunya virus (CHIKV) infection models with antibodies. We incorporate two modes of infections, attaching a CHIKV to a host monocyte, and contacting an infected monocyte with an uninfected monocyte. The CHIKV-monocyte and infected-monocyte incidence rates are given by saturation. In the second model we consider two classes of infected monocytes, latently infected monocytes and actively infected monocytes. The global stability analysis of the equilibria are established using Lyapunov method. We support our theoretical results by numerical simulations.