Effect of caseinphosphopeptide on absorbability of co-ingested calcium in normal postmenopausal women

Abstract

Caseinphosphopeptide in a dose of 87.5 mg was administered to 35 normal post-menopausal women as a part of a standard test meal containing a calcium load of 250 mg. Absorption of calcium was tested both with and without caseinphosphopeptide, using an intrinsic45Ca label in the calcium source. The mean quotient of absorption with/without caseinphosphopeptide was greater than 1.0, but nonsignificantly so. However, when analysis was confined to women with low absorption values, caseinphosphopeptide administration was associated with significantly better absorption of co-ingested calcium. Those findings suggest that caseinphosphopeptide supplementation is particularly useful, for persons with low basal absorptive performance. © 1994 Japanese Society of Bone Metabolism Research.