Neocollagenesis in Non-Invasive Aesthetic Treatments

Abstract

Dermal neocollagenesis is often assumed to be the main reason of visible skin improvement after different non-invasive and minimal invasive aesthetic treatments. However, the very slow dynamics of the mature collagen remodelling in the extra cellular matrix (ECM) of dermis, with a half-life time of 15 years, renders every observable upregulation of colla- gen production insufficient to replace a significant part of the matrix during the short time in which it is claimed skin improvement takes place.