Galega officinalis L. and Immunological Status in Diabetes Mellitus

Abstract

Under diabetes mellitus, the administration of Galega officinalis promotes restoration of leukocyte precursors' bone marrow pool and normalizes their prolifera-tive activity. This plant protects the functional state of leukocytes by modulating actin cytoskeleton formation and through quantitative redistribution of leukocyte membrane glycoconjugates. Galega officinalis prevents the development of diabetes-associated oxidative stress which results in antiapoptotic activity. The normalization of leukocytes' proliferative and functional capacity by Galega officinalis, along with its antiapoptotic and hypoglycemic effects, can improve the course of the disease and may prevent the development of complications of diabetes.