Measurement and correlation of solubility of olmesartan medoxomil in six green solvents at 295.15-330.15 K

Abstract

The aim of present study was to measure and correlate the mole fraction solubility of olmesartan medoxomil (OLM) in six green solvents, namely, water, ethanol, propylene glycol (PG), polyethylene glycol-400 (PEG-400), ethylene glycol (EG), and Transcutol from (295.15 to 330.15) K at atmospheric pressure using the shake flask method. The experimental solubilities of OLM were correlated with the Apelblat equation. The root-mean-square deviations between experimental and calculated solubility were observed in the range of 3.360 × 10-8 to 0.013 × 10-3 in all green solvents. However, the correlation coefficients in water, ethanol, PG, PEG-400, EG, and Transcutol were observed in the range of 0.996-0.998, indicating a good fit. The solubility of OLM was found to be higher in PEG-400 (2.58 × 10 -3 at 298.15 K) and Transcutol (2.48 × 10-3 at 298.15 K) as compared to water (2.32 × 10-7 at 298.15 K), ethanol (4.67 × 10-4 at 298.15 K), PG (9.23 × 10 -5 at 298.15 K) and EG (6.73 × 10-5 at 298.15 K). © 2014 American Chemical Society.