Racemic trans-1,2-diaminocyclohexane as a template in the synthesis of ligands for transition metal and actinide in vivo detoxification

Abstract

Racemic trans-1,2-diaminocyclohexane was used as a template for building EDTA-like derivatives that might act as strong complexation agents in vivo. Cyclohexane diamino tetraphosphonate (CDTP) and diamino diphosphonate (CDDP) ligands were synthesized for use in the detoxification of living organisms of heavy atoms or actinides following accidental ingestion. The stability of the complexes with calcium, copper, and cobalt were studied in vitro and compared to those of EDTA or DTPA. The X-ray structures of CDDP and CDTP confirm their strong ability to form highly stable complexes.