Ondansetron and granisetron in the prophylaxis of nausea and emesis induced by cisplatin in dogs

Abstract

In the present study, the effects of 5-HT3 receptor antagonist granisetron and ondansetron on the acute phase of cisplatin-induced nausea and emesis were analyzed in dogs. Fifteen healty dogs were used in this study. Cisplatin was administrated to all dogs to induce nausea and vomiting. All dogs that received cisplatin (3 mg/kg IV) were observed continuously for 8 h. Five dogs administered only cisplatin acted as controls. Cisplatin induced emetic response and nausea was detected in the controls. Ondansetron (1 mg/kg IV) and granisetron (60 μg/kg IV) were administered to the other animals 30 min. before cisplatin administration. Although acute vomiting was significantly inhibited by ondansetron and granisetron, granisetron was found more effective on the nausea. It was concluded that both ondansetron and granisetron are effective in the control of cisplatin-induced vomiting in dogs, but granisetron is more effective than ondansetron in the inhibition of cisplatin-induced nausea in dogs.