Neurolysin knockout mice generation and initial phenotype characterization

Abstract

Background: Neurolysin is known to cleave several bioactive peptides in vitro. Results: Neurolysin knock-out mice showed increased glucose tolerance, insulin sensitivity, and gluconeogenesis, which likely relates to increased expression of both specific liver mRNAs and intracellular peptides. Conclusion: Neurolysin plays a role in energy metabolism. Significance: Neurolysin could be used as a therapeutic target to counteract insulin resistance. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.