Silver nanowires as prospective carriers for drug delivery in cancer treatment: An in vitro biocompatibility study on lung adenocarcinoma cells and fibroblasts

Abstract

Lung cancer is a major and increasing global health problem. While there have been significant advances in the understanding of lung cancer biology, still no current therapy exists to reduce the inevitable and lethal progression of this disease. Silver nanowires (AgNWs) are promising candidates for a wide range of biomedical applications and the treatment of life-threatening diseases due to their unique physico-chemical and biochemical properties. However, the safety of this nanomaterial and its use as a biomedical tool are still under debate. This study evaluates the in vitro internalisation, cytotoxicity and influence on the cell cycle of AgNWs in lung adenocarcinoma (A549) cells and lung normal fibroblasts (MRC-5 cells). Our results demonstrate that AgNWs could be internalised effectively into A549 and MRC-5 cells without inducing detectable cytotoxicity, thus providing preliminary evidence on the future potential of AgNWs as biocompatible drug delivery platforms applicable in lung cancer therapies. © 2013 by Walter de Gruyter Berlin Boston.