Patterns of serological markers for cellular immune activation in patients with dilated cardiomyopathy and chronic myocarditis

Abstract

We determined serum concentrations of neopterin and β2-microglobulin, soluble markers of cellular immune activation, in 27 patients with either dilated cardiomyopathy (DCM) or chronic myocarditis. Neopterin and β2-microglobulin concentrations were respectively increased in 2 and 5 of 11 patients with DCM and in 11 and 9 of 16 patients with chronic myocarditis. A higher cardiac functional class (according to the New York Heart Association) was associated with greater neopterin and β2-microglobulin concentrations. During follow-up of patients, both neopterin and β2-microglobulin concentrations in serum correlated with the course of disease. Additionally, correlations were significant between left ventricular functional tests (end-diastolic volume, end-systolic volume, and ejection fraction) and neopterin and β2-microglobulin concentrations. We conclude that measurement of neopterin and β2-microglobulin are useful to monitor disease development in patients with myocardial inflammation.