Fabrication of Scaffold based on Chitosan - Poly-2-Acrylamido- 2-Methylpropane Sulfonic Acid (PAMPS) Polyelectrolyte Complexes

Abstract

Chitosan is considered as one of the best biopolymers for bone tissue engineering application due to its appealing properties such as biocompatible, non-toxic, non-immunogenic, able to accelerate growth rate of bone tissue, possess antibacterial activity and able to form porous structure. Herein, polyelectrolyte complexes (PECs) prepared by simple mixing of chitosan solution and poly-2-acrylamido-2-methylpropane sulfonic acid (PAMPS) solution were investigated. In this study, chitosan concentration were varied from 1.0 to 2.0% (w/v), while concentration of AMPS was fixed at 0.1% (w/v) to know the influence of chitosan concentration on swelling capacity and mechanical properties of obtained PECs. Swelling test and compressive test results showed that the most stable PECs in aqueous environment with highest ultimate compressive strength was PECs obtained from chitosan 2.0% (w/v) - PAMPS 0.1% (w/v) with swelling capacity 3,326% for 2 hours and ultimate compressive strength 1.22 kPa.