Cytotoxic and antimicrobial activities of two new synthetic 2′-oxygenated flavones reported from Andrographis viscosula

Abstract

Two new 2′-oxygenated flavones have been synthesized via chalcone precursors and the biocidal activity of these two flavones, along with the corresponding chalcones against microbes (bacteria and fungi) and brine shrimp nauplii were investigated. Both the flavones (compounds 6 and 7) and their corresponding chalcones (compounds 4 and 5) showed good activity against all the tested bacterial and fungal strains. The LC50 values of compounds 4- 7 were found to be 2.31, 0.94, 1.39 and 0.58 μg mL-1, respectively. The synthesized compounds were characterized using UV-Vis, IR, 1H-NMR and 13C-NMR spectral data, together with elemental analysis.