Seasonal changes in the prevalence of antibiotic-susceptible acinetobacter calcoaceticus-baumannii complex isolates result in increased multidrug resistance rates during winter months

Abstract

Temporal analysis of Acinetobacter calcoaceticus-baumannii complex isolates in a large, US healthcare system demonstrated decreased occurrence of antibiotic-susceptible isolates between November and May, while resistant isolate occurrence was temporally stable. This resulted in 50%-100% seasonal increases of resistance rates. This work offers insight into the phenomenon of Gram-negative pathogen seasonality.