Microwave-assisted reaction of 2,3-dichloronaphthoquinone with aminopyridines

Abstract

The synthesis of pyridylaminonaphthoquinones by microwave-assisted reaction of 2,3-dichloro-1,4-naphthoquinone with aminopyridines is described. The use of microwave irradiation diminished the reaction times and improved the yields substantially in all these reactions. The compounds were tested for their cytotoxic activities against MCF-7 breast cancer cell line. ©2009 Sociedade Brasileira de Química.