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Myeloid-derived suppressor cell mitochondrial fitness governs chemotherapeutic efficacy in hematologic malignancies

Nature Communications (2024) 15(1)
DOI: 10.1038/s41467-024-47096-9
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Abstract

Myeloid derived suppressor cells (MDSC) are associated with tumourigenesis and therapy response. Here, the authors show that beta 2-adrenergic receptor activation in MDSC leads to metabolic rewiring which regulates chemotherapy response in preclinical models of blood cancer.

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Daneshmandi, S., Choi, J. E., Yan, Q., MacDonald, C. R., Pandey, M., Goruganthu, M., … Mohammadpour, H. (2024). Myeloid-derived suppressor cell mitochondrial fitness governs chemotherapeutic efficacy in hematologic malignancies. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-47096-9

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