Whole-genome analysis of Ligilactobacillus salivarius L33, a potential probiotic strain isolated from chicken gastrointestinal tract

Abstract

Ligilactobacillus salivarius is a well-studied probiotic with proven benefits in poultry farming, including improved growth and reduced pathogen colonization. This study characterizes a novel strain, L. salivarius L33, isolated from broiler chickens, and demonstrates its potential as a probiotic through genomic and functional analyses. The strain’s genome reveals genes linked to stress tolerance, gut adhesion, and antimicrobial activity, including salivaricin, a bacteriocin with broad anti-pathogen effects. These findings are significant because they highlight L33’s promise as a natural, safe alternative to antibiotics in poultry production, aligning with global efforts to reduce antimicrobial resistance. Further development of this strain could enhance animal health, productivity, and food safety, offering economic and public health benefits.