Recent Developments for the Ring Opening of Pyrrolidines and Unstrained Cyclic Amines via C−N Bond Cleavage

Abstract

In recent years, the deconstructive transformation of unstrained cyclic amines via C−N bond cleavage has emerged as a powerful strategy for expanding chemical space and facilitating the synthesis of structurally diverse molecules. Notably, advancements in the C−N bond cleavage of pyrrolidine and other unstrained cyclic amines have highlighted the significant potential of this approach in modern organic synthesis. This concept reviews recent developments in the C−N bond cleavage reaction, with a primary focus on pyrrolidines, while also exploring broader progress in related systems.