ATM activation mediates anticancer immunosurveillance by natural killer and T cells

Abstract

The DNA damage response (DDR), which is frequently activated in cancer cells, has been proposed to operate as an early barrier against oncogenesis. We have recently shown that ATM mediates the spontaneous regression of Eμ-myc-driven murine B-cell leukemia in a natural killer and T cell-dependent manner. The DDR partially enhancedimmune recognition by stimulating the expression of the DNAM-1 ligand CD155. © 2013 Landes Bioscience.