Dry Syrup: A Comprehensive Review

Abstract

The oral dosage forms are most popular because of their ease of administration, patient compliance, and formulation stability. Tablets and capsules, the most popular oral dosage form, have the drawback of difficulty swallowing the dosage form specially developed for pediatric and geriatric patients. In recent times the, modern scientific and technological advancement in pharmaceutical field has created a bank of interest in the reconstitutable oral suspension (Dry syrup). Dry syrups are the dry mixtures that require adding water at the dispensing time. Dry syrups show adequate chemical stability of drug during shelf life and reduce the final product's weight. Moreover, dry syrups show higher bioavailability than tablets and capsules as they disintegrate in water outside the oral cavity and directly enter the gastrointestinal tract. Most of the drugs prepared as dry powders for oral suspensions are antibiotics. The present review gives an account of the excipients used, methods of preparation of dry syrup, their evaluation, and their packaging. When manufacturing dry syrup medicine, the dry mixture should have a uniform concentration of the required ingredients. This ensures that the drug does not break up into a non-homogeneous mixture when reconstituted, which may lead to errors in dosage. The items used in the manufacturing of dry syrup include excipients, granule disintegrating, granule binder and powder blends. Excipients are used to stabilize active ingredients for a long period. The type of excipient used is based on the suitability for reconstitution and the type of the powder the granule disintegrate helps ensure the dry syrup particles do not aggregate during reconstitution. The granule binder helps ensure that the dry syrup's particles settle in the suspension.